危险点预控技术在电网调度中的应用

介绍了电网调度危险点预控的一般概念以及危险点的特点和产生原因.从杭州电网调度工作的实际出发,分析归纳出杭州电网调度工作产生风险的主要危险点.针对危险点,提出了对策以及危险点预控的步骤,并在杭州电网调度SCADA系统中实施应用.     

雪莲果汁澄清剂比较研究

为得到澄清的雪莲果汁,对5种澄清剂在雪莲果汁中的澄清效果进行了比较研究,通过比较果汁透光率、吸光度的变化,确定雪莲果汁适宜的澄清剂。试验结果表明：壳聚糖、明胶、果胶酶、单宁、硅藻土对雪莲果汁均有一定的澄清效果。其中,壳聚糖的澄清作用时间最短,澄清效果明显优于其它几种澄清剂,且对果汁品质无明显影响,其最适添加量为0.72g/L;明胶的适宜用量为1.44g/L,果胶酶为0.20g/L,单宁为0.96g/L,硅藻土为0.24g/L,这4种澄清剂的澄清效果差异并不显著。壳聚糖为雪莲果汁适宜的澄清剂。     

基于SOA架构运用SAP XI实现卷烟工业企业一体化信息集成平台的应用研究

为有效集成卷烟工业企业的众多管理信息系统、整合现有信息资源,以浙江中烟工业有限责任公司信息系统建设为例,基于SOA架构运用SAP XI(Exchange Infrastructure,XI)构建了卷烟工业企业一体化信息集成平台.该集成体系将所有需要连接的系统,建立以SAP XI为中心Hub的星形连接,简化了多系统集成时的复杂度;SAP XI将所有由源系统传来的数据格式进行转换处理.实现了异构系统之间的通信集成;SAP XI服务总线将国家局、省级公司、制造部不同信息系统互相衔接,实现了不同层级多个业务系统之间的无缝集成.信息集成平台应用后,实现了多套应用系统之间的总线式信息交互,从架构层面确保了企业各应用系统之间进行灵活、有序、可控的信息交互,解决了信息孤岛、数据质量、流程整合等问题,对卷烟工业企业开展信息化建设提供了借鉴和参考.     

黄芩苷对H2O2氧化损伤人黑素细胞的保护机制研究

目的:探讨黄芩苷对H2O2氧化损伤正常人黑素细胞的保护作用及其机制研究。方法:构建H2O2氧化损伤黑素细胞模型，通过观察不同浓度的黄芩苷处理H2O2氧化损伤正常人黑素细胞，采用倒置显微镜观察黄芩苷对黑素细胞形态的影响；cell counting kit-8（CCK-8）法检测黄芩苷对黑素细胞增殖活力作用；乳酸脱氢酶（lactate dehydrogenase,LDH）法检测黄芩苷对黑素细胞LDH表达的影响, 并通过流式细胞仪检测活性氧（ROS）水平，荧光实时定量RT-PCR检测过氧化氢酶（catalase,CAT）、谷胱甘肽过氧化物酶1（peroxidase 1,GPX1）mRNA表达情况，通过ELISA试剂盒检测黄芩苷和H2O2处理黑素细胞后分泌的热休克蛋白70（heat shock protein 70,HSP70）。结果:镜下观察黄芩苷给药后细胞较对照组形态明显改变，细胞数增多；黄芩苷作用黑素细胞后增殖率较对照组升高（P<0.05）；黄芩苷明显抑制黑素细胞中LDH表达，呈剂量-效应关系（P<0.05）。黄芩苷能显著促进CAT和GPX1 mRNA表达，且明显抑制HSP70分泌。结论:黄芩苷对H2O2氧化损伤的正常人黑素细胞具有明显保护作用，可为临床白癜风的治疗提供参考。     

Antimicrobial susceptibility of isolated pathogens from patients with contact lens-related bacterial keratitis in Crete,Greece: A ten-year analysis

PurposeTo evaluate the bacterial spectrum and antimicrobial susceptibilities of pathogens isolated from contact lens-related bacterial keratitis cases in a large academic Greek hospital.MethodsAll adult patients with positive corneal scrapings or contact lens culture between 2007 and 2016 at the University Hospital of Heraklion, Greece, were retrospectively identified through a local microbiology database and their medical records were reviewed.ResultsA total of 240 isolates were recovered from 131 patients with culture-proven contact lens-associated bacterial keratitis. The most common microorganism identified was Serratia marcescens (17.1% of total isolates), followed by Pseudomonas aeruginosa, Klebsiella spp. and coagulase-negative staphylococci (CoNS). Rates of aztreonam-resistant P. aeruginosa and erythromycin-resistant CoNS decreased in recent years, while the decrease in oxacillin-resistant CoNS was statistically significant (p=0.009). More than 90% of the isolated organisms (S. marcescens, P. aeruginosa, Klebsiella spp. and CoNS) were susceptible to ciprofloxacin or gentamicin.ConclusionGram-negative microorganisms are the most common causative pathogens of contact lens-related keratitis in the region of Crete. Topical antibacterials containing quinolones or gentamicin represent an effective empirical treatment for the majority of the cases. This is quite encouraging, considering that the present study was conducted in a country characterised by high antimicrobial resistance rates. However, culture-driven antimicrobial treatment is mandatory for this sight-threatening infection.     

Ultrasonic Cavitation-Assisted and Acid-Activated Transcytosis of Liposomes for Universal Active Tumor Penetration

Active tumor penetration has been recently recognized as a promising strategy to resolve the limitation of nanomedicine in terms of tumor penetration, but it is challenging to develop active transporting nanocarriers. Here, an ultrasonic cavitation-assisted and acid-activatable active transporting liposome for a broad range of tumors is reported. The active transporting liposome (size and charge dual-conversional gemcitabine prodrug-integrated liposomal nanodroplet (SCGLN)) overcomes the tight blood vessel walls with the aid of ultrasonic cavitation. The SCGLN subsequently transforms from micro-size to nano-size under prolonged ultrasound radiation. Once in the acidic tumor microenvironment, the nanosized SCGLN undergoes negative-to-positive charge-reversal and triggers the cationization-initiated transcytosis to penetrate deep into tumor parenchyma. The gemcitabine-loaded SCGLN exhibits potent antitumor activity in multiple poorly permeable tumor models, which completely erases subcutaneous U251 glioma and stops the progression of orthotopic BxPC3 pancreatic ductal adenocarcinoma. This study presents a promising and universal strategy to develop active penetrating nanomedicines for efficient drug delivery in the low permeable tumor.     

PCN-Fe(III)-PTX nanoparticles for MRI guided high efficiency chemo-photodynamic therapy in pancreatic cancer through alleviating tumor hypoxia

As nanomedicine-based clinical strategies have continued to develop, the possibility of combining chemotherapy and singlet oxygen-dependent photodynamic therapy (PDT) to treat pancreatic cancer (PaC) has emerged as a viable therapeutic modality. The efficacy of such an approach, however, is likely to be constrained by the mechanisms of drug release and tumor oxygen levels. In the present study, we developed an Fe(III)-complexed porous coordination network (PCN) which we then used to encapsulate PTX (PCN-Fe(III)-PTX) nanoparticles (NPs) in order to treat PaC via a combination of chemotherapy and PDT. The resultant NPs were able to release drug in response to both laser irradiation and pH changes to promote drug accumulation within tumors. Furthermore, through a Fe(III)-based Fenton-like reaction these NPs were able to convert H₂O₂ in the tumor site to O₂, thereby regulating local hypoxic conditions and enhancing the efficacy of PDT approaches. Also these NPs were suitable for use as a T₁-MRI weighted contrast agent, making them viable for monitoring therapeutic efficacy upon treatment. Our results in both cell line and animal models of PaC suggest that these NPs represent an ideal agent for mediating effective MRI-guided chemotherapy-PDT, giving them great promise for the clinical treatment of PaC.

     

基于BOA-ELM的混凝土抗压强度预测研究

为控制控制混凝土生产成本,在混凝土拌和期限制抗压强度不足的缺陷构建产出,可以有效降低原料的浪费,是节能降耗的关键方法之一。针对混凝土抗压强度的传统测量方法严重滞后的问题,提出了基于贝叶斯优化极限学习机(BOA-ELM)的混凝土抗压强度预测方法。首先,分析了混凝土拌和过程中对抗压强度预测值实时获得的需求。以各物料的用量为分析基础,28天标准养护后混凝土抗压强度值为预测目标,设计了基于极限学习机的强度预测模型。其次,为进一步提高模型的稳定性以及准确行,提出基于贝叶斯优化的极限学习机模型,根据模型超参数的分布特征,以高斯过程作为超参的先验分布,预测误差最小化作为目标,寻找最优的模型超参。最后,在实际施工产生的C50标号混凝土数据集上测试文中模型,并对比分析了其他预测模型和寻优算法。结果表明,结合了贝叶斯优化的极限学习机预测模型相较于经典算法具有更高的预测准确性和模型训练的高效性。     

基于X射线检测的电力电缆常见缺陷分析

X射线数字成像技术由于高灵敏度、无损检测等优势,可以检测出常规手段较难直观判断的设备缺陷部位及老化状况,近年来在电力电缆的缺陷检测中的应用越来越多。本文在阐述了X射线检测原理和检测参数的基础上,例举了2个X射线检测现场受损电缆的实际案例。在电缆外护套受损的情况下,通过X射线成像,可以快速判断主绝缘层是否有缺陷。非破坏性的X射线检测方法是一种高效的、节约成本的现场检测技术。     

Bioinspired Tumor Calcification Enables Early Detection and Elimination of Lung Cancer

Precise diagnosis of cancer in an early stage and treatments with a reliable response, high selectivity, and negligible side effects is urgently needed. However, current cancer management involves low-resolution metrics and delayed visual confirmation of tumor foci in imaging findings, and the toxicity of chemo- and radiotherapy unavoidably damages normal tissue and disrupts the immune balance of cancer patients. Here, a polypeptide is synthesized that preferentially targets lung cancer cells rather than normal lung epithelial cells and induces calcium precipitation specifically on the plasma membrane of lung cancer cells without additional supplementary calcium. Polypeptide-induced cellular calcification can ideally facilitate medical imaging for identifying early-stage lung cancer and distinguish cancer from benign nodules. Physiological and spontaneous calcification of tumors is induced by polypeptides and sharply prolongs the survival of tumor-bearing mice without evidence of systemic side effects. This tumor cell-selective calcification process provides an attractive, safe, and unprecedented approach for accurately visualizing and treating cancer in patients with early-stage disease in the clinic. It has broad implications in developing simple physiological reactions for diagnosing and treating cancer and provides a new horizon for drug discovery.